Effect Of Aqueous Extracts of Chamomile and Arabic Gum On Indomethacin- Induced Toxicity In Rats

Arabic gum has been used as anti-inflammatory agent and chamomile has anti-inflammatory and antioxidant properties.This study investigated the efficacy of aqueous extracts of chamomile and Arabic gum on the toxic side effects of indomethacin in male albino rats. Thirty male albino rats (185±10 g) were divided into six groups, one of them was kept as a (-ve) control group (5 rats), while the other groups 25 rats were treated orally with indomethacin (25mg / kg b.Wt.) once daily for twenty-one (21) days. One group was kept as (+ve) control group, while others were given aqueous extracts of chamomile for 2 groups and Arabic gum for the other 2 groups(500 and 1000 mg/kg) orally daily. Feed intake (FI), body weight gain % (BWG %) and feed efficiency ratio (FER) were carried out. Serum glutamic oxaloacetic transaminase(GOT) and serum glutamic pyruvic transaminase (GPT) were evaluated. Serum creatinine and urea were analyzed. Red blood cell and white blood cells count were measured. Hemoglobin concentration was estimated. Also, histopathological changes for liver were examined.The obtained results concluded that using the tested drinks improved previous mentioned parameters. The best results were obtained on using the high doses of aqueous extracts. According to the results, the author recommended the trial on human beings.