Nightmares Associated to Nevirapine during Chemoradiotherapy for Carcinoma Tongue

Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) is a drug used in the management and treatment of HIV. It is considered safe for use in conjunction with platinum-based chemotherapy. Chemotherapy is a staple of cancer treatment and is used routinely in the management of malignancies of the head and neck. However, managing HIV-positive cancers presents challenges due to individual side effects and drug interactions. Drug interactions can potentiate or reduce drug metabolism, reduce excretion, or cause adverse drug reactions.

Herein, we describe a case of new-onset nevirapine-induced nightmares that was noted in a patient undergoing chemoradiotherapy with cisplatin.