Recent Study on Synthesis of Novel Series of Quinolino [3,2-f][1,2,4] triazolo [3,4-b][1,3,4] Thiadiazepines Derivatives Incorporated with 3-(5- (benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl) Moiety as Potent Antimicrobial Agent

A novel series of Quinolino[3,2-f] [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine derivatives (7a-i)
incorporated with 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl) moiety were synthesized through
one-pot cyclo-condensation reaction of 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-
1,2,4-triazole-3-thiol (4) with 2-chloro-quinoline-3-carbaldehyde derivatives (6a-i) in presence of
K2CO3 in DMF. The characterization of newly synthesized compounds 3-(5-(benzofuran-2-yl)-1-
phenyl-1H-pyrazol-3-yl)-substituted quinolino [3,2-f][1,2,4] triazolo[3,4-b] [1,3,4]thiadiazepines was
made by elemental analysis and spectral studies such as FT-IR, 1H NMR and 13C NMR, further
supported by Mass spectra. All the synthesized compounds were screened in-vitro for their
antimicrobial activities against panel of pathogenic microorganism bacterial strains, S. aureus E.coli,
P.vulgaris, S.typhi at different concentration. The result of bioassay when compared with
Chloramphenicol indicated good to moderate activity against these microbial strains. We have
synthesized titled 1,3,4-thiadiazepines derivatives by economic, better yield, and safer methods
through cyclocondensation of 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-1,2,4-
triazole-3-thiol with 2-chloro-quinoline-3-carbaldehyde derivatives in DMF as a solvent. Their purity
and confirmation was established by physical, analytical and spectral data. The compounds 7a-f were
investigated for their antimicrobial screening and observed that these compounds were found to
posses excellent to moderate activity against selected strains of bacteria.