A Rare Clinical Representation of Graves’ Disease and Marine Lenhart Syndrome

The aim of this study is to review and discuss the clinical features and treatment options for the
Marine-Lenhart syndrome, an uncommon thyroid disturb. The methodology adopted was a
bibliographic research. The results of this study show that different mechanisms are implicated in the
pathogenesis of Graves’ disease and in the nodular formation of thyroid tissue with functional
autonomy. Graves’ disease is caused by an autoimmune process that involves the entire thyroid
gland and is characterized by the presence of TSH receptor stimulating antibodies. The present study
concludes that caution should be exercised in interpreting thyroid disease in Graves’ disease. The
treatment of thyrotoxicosis requires high doses of oral drugs. Relapsing anti-thyroid therapy occurs
soon after oral antithyroid therapy is discontinued. This presentation should alert the physician about
the existence of toxic nodules, and about the possibility of a Marine-Lenhart Syndrome. The treatment
of thyrotoxicosis requires high doses of oral, or relapsing antithyroid therapy occurs soon after oral
antithyroid therapy is discontinued. This should alert the doctor about the existence of toxic nodules,
thus Marine-Lenhart Syndrome. More research on this topic is needed to further understand the
mechanisms involved in this clinical entity.