COMPARATIVE ASSESSMENT OF MELIORATIVE EFFECTS OF Syzigium cumuni AND Carica papaya ON REPRODUCTIVE PHYSIOLOGY OF HYPERGLYCEMIC Mus musculus WITH RESPECT TO MALE

Hyperglycemia or high blood glucose means there is too much glucose in blood because the body lacks enough insulin. Plants and plants based herbal products have been active to prevent numerous diseases since very very long ago.Out of plants Syzigium cumuni and Carica papaya from Myrtaceae and Caricaceae family respectively, are perennial usually unbranched. Both plants have a meliorative role against several human diseases due to presence of very rich source of minerals, vitamins and phytochemicals. This study was designed to induce hyperglycemia by alloxan and to investigate the comparative effect of Syzigium cumuni and Carica papaya on reproductive physiology of hyperglycemic Mus musculus with respect to male. Mice were grouped as Group I, Group II, Group III and Group IV. Group II were made hyperglycemic by instigating alloxan (450 mg/kg bw) and then were given stipulated doses of (200 mg/kg bw) Syzigium cumuni seed powder and Carica papaya leaves extract to Group III and Group IV respectively for 21days.Mice were sacrificed and cauda epididymis were incised ,put into 9:1 suspension and various sperm parameters were observed and compared. The results of the study suggest that S. cumuni seed powder and Carica papaya leaves extract contain almost similar phytoconstituents which can be used as a supplementary or alternative herbal remedy for the treatment of hyperglycemia and its related complications. Further investgations involving constituents of the S. cumuni seed powder and Carica papaya leaves extract can be a good platform for the development of a new horizon for antihyperglycemic drugs.