Yuasa, Yoshifumi (2021) Determining the Practical Synthesis and Purification of cis-11-Octadecenoic Acid: A Component of Inhibition of Endotoxin Response. In: Challenges and Advances in Chemical Science Vol. 6. B P International, pp. 37-42. ISBN 978-93-5547-106-2
Full text not available from this repository.Abstract
This study report the practical and effective synthesis of 1 with respect to provide a high purity of this useful chemical. cis-11-Octadecenoic acid 1, which is known to be a useful chemical for the component of drugs, has been synthesized by Wittig reaction with n-heptanal and 10-methoxycarbonyldecyltriphenylphosphonium bromide using potassium t-butoxide at –50°C to give methyl cis-11-octadecenoate 2 in 79% yield with 95% cis-selectivity, followed by hydrolysis and then recrystallizated by MeOH at –20°C to give a high purity of 1 in 33% yield.
| Item Type: | Book Section |
|---|---|
| Subjects: | Eprints AP open Archive > Chemical Science |
| Depositing User: | Unnamed user with email admin@eprints.apopenarchive.com |
| Date Deposited: | 19 Oct 2023 08:07 |
| Last Modified: | 19 Oct 2023 08:07 |
| URI: | http://asian.go4sending.com/id/eprint/1362 |
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