Wound Healing Potential of GTN in Wistar Rats

Objective: The present study was undertaken to determine wound healing potential of Glyceryl trinitrate in wistar rats.

Materials and Methods: 18 male wistar rats were taken, divided in three groups, 6 rats per group Control (Normal saline), Glyceryl trinitrate, Ointment base. The nape of neck was shaved, they were starved overnight and on next day surgical intervention under general anaesthesia was done. 500 mm2 excisional wound, circular in shape was created with scalpel blade. Topical application of drugs that is Glyceryl trinitrate, control and Ointment base was done since next day of wounding. Wound was traced with polythene paper and area was measured with help of planimeter on 6th day, 10th day, y and 14th day.

Result: Two parameters were studied viz; wound contraction and period of epithelization. Glyceryl trinitrate has shown statistically signficant difference in wound contraction compared to control. Period of epithelization was also reduced significantly by Glyceryl trinitrate compared to Control and Ointment base treated groups.