Assessing the Dynamics of Antioxidant Protection of Tear Fluid and Retrobulbar Blood Circulation in Diabetic Retinopathy

Diabetes retinopathy (DR) is a vascular complication of diabetes that causes vision loss and blindness in people of all ages. The objective of this study was to determine the biochemical parameters of the lacrimal fluid and color Doppler imaging (CDI) of the diabetic eyes, the effectiveness of tanakan endonasal electrophoresis in the treatment of non-proliferative diabetic retinopathy (NPDR). This prospective study included 165 patients with NPDR who were randomly allocated to receive traditional treatment (control group), daily tablets of Tanakan (TT group), or daily endonasal electrophoresis of Tanakan (TE group) within ten days. The severity scale of the Early Treatment Diabetic Retinopathy Study(ETDRS) was used to determine the stages of DR. The main outcome measures were changes in DR severity (DRS), antioxidant activity of tears, and CDI at months 1, 3, and 6. This study has shown a gradual decrease in NO levels as DRS increases. Moderate negative correlations were found between peak systolic velocity (PSV) of the central retinal artery (CRA), central retinal vein (CRV), short posterior ciliary artery (SPCA) and DRS, end-diastolic velocity (EDV) of CRA and DRS. CDI with results of increased resistance or decreased flow can be used to predict higher risk for developing severe DR, which is essential for determining further patient management tactics.