A Case-control Study to Assess Bone Mineral Status in Sub-clinical Hypothyroidism

Introduction: The most prevalent thyroid condition, hypothyroidism, causes a number of metabolic abnormalities.

The most typical imbalance is caused by an irregularity in the minerals that make up the bones, calcium and phosphorus.

Considering that people with thyroid hormone imbalance don't have any symptoms, sub-clinical hypothyroidism is frequently neglected.

The Thyroid Stimulating Hormone (TSH) level is used to make an incidental diagnosis of sub-clinical hypothyroidism.

In this condition, there is no change in the levels of the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine) in the blood.

Aim: Studying the Ca/P ratio, a precursor to osteoporotic markers in hypothyroid individuals, is the goal.

Materials and Methods: This case-control study included 35 individuals with normal thyroid function as controls and 35 individuals with sub-clinical hypothyroidism, all of whom were between the ages of 20 and 45. The appropriate procedures were used to determine the levels of calcium and phosphorus in the serum samples. To keep the parameters stable, the samples were examined on the same day. Calculated was the calcium/phosphorus ratio (Ca/P).

Results: When compared to the control group, blood calcium levels in sub-clinical hypothyroidism were found to be lower (8.330.30) and serum phosphorus levels to be higher (6.610.88). As a result, a change in the Ca/P ratio of (1.260.34) was observed.

Conclusion: This study emphasises the need for people with subclinical hypothyroidism to have their bone mineral status checked in order to prevent difficulties with their bone health.