Identification of the Regioselectivity of the Thermal Huisgen 1,3-Dipolar Cycloaddition Reaction between an Azide Derivative and a Synthetic Heterocyclic Alkyne, through a Comparative Study of NMR Spectral Data

Aouine, Younas and Boukhssas, Salaheddine and Alami, Anouar and Faraj, Hassane and Hallaoui, Abdelilah El (2020) Identification of the Regioselectivity of the Thermal Huisgen 1,3-Dipolar Cycloaddition Reaction between an Azide Derivative and a Synthetic Heterocyclic Alkyne, through a Comparative Study of NMR Spectral Data. In: Theory and Applications of Chemistry Vol. 4. B P International, pp. 116-124. ISBN 978-93-89816-29-7

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Abstract

The 1,3-dipolar cycloaddition reaction between 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole
and 9-(prop-2-ynyl)-9H-carbazole, in toluene at reflux, leads to obtain two regioisomers with different
proportions where the 1,4-regioisomer is generally more prominent than 1,5-regioisomer. The
assignment of structures to 1,2,3-triazolic regioisomers was established in base of a comparative
study of NMR spectral data (1H, 13C, 15N and 2D 1H-15N HMBC spectra) in addition to the elemental
analysis and MS data

Item Type: Book Section
Subjects: Eprints AP open Archive > Chemical Science
Depositing User: Unnamed user with email admin@eprints.apopenarchive.com
Date Deposited: 25 Nov 2023 07:59
Last Modified: 25 Nov 2023 07:59
URI: http://asian.go4sending.com/id/eprint/1687

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