TRANSGENERATIONAL REPERCUSSION OF PATERNAL DIABETES ON BLOOD GLUOSE LEVEL OF F-1 MALE LITTERS Mus musculus AND THEIR PROBABLE RECUPERATION USING Syzigium cumuni SEED POWDER

Hyperglycemic condition was induced in male mice by injecting Alloxan Monohydrate which led to deficiency in insulin secretion in the mice followed by offsprings of F1 generation, obtained after mating diabetic male with normal female.

The aim of study was to investigate the ameliorative effect of Syzigium cumuni seed powder on blood glucose level of F1 male generation obtained when diabetic male mice was mated with normal female .Fixed dose of syzigium cumuni seed powder were given along with food to F1 generation and blood glucose level were observed at a regular intervals for three weeks.

Syzigium cumuni seed powder restores the histoarchitecture of pancreatic β cells and stimulates the secretion of pancreatic insulin in F1 generation of male mice. Blood glucose level were found to return to their normal levels. Significant reduction in the alterations or abnormalities (i.e. smaller and more irregular shaped islets) in F1 male mice generation were noticed.

Hyperglycemia may influence the epigenetic modifications during spermatogenesis and these epigenetic alterations in pancreatic structures cannot be normalized by providing normal diet implying that these changes were trangenerational and may be inherited through male germ line and passed onto more than one generations.

In near future, transgenerational /epigenetic factors may be regarded as important aspect in determining risk of diabetes.