Research on Transungual Delivery of Ciclopirox is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an in vitro Model

Díaz, Damian Cordoba and Iglesias, Marta Elena Losa and Vallejo, Ricardo Becerro de Bengoa and Diaz, Manuel Cordoba (2021) Research on Transungual Delivery of Ciclopirox is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an in vitro Model. In: Technological Innovation in Pharmaceutical Research Vol. 3. B P International, pp. 1-8. ISBN 978-93-90888-30-6

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Abstract

Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3–4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition. The in vitro model described herein would be an excellent system to directly measure transungual delivery of antifungal agents prior to clinical trials.

Item Type: Book Section
Subjects: Eprints AP open Archive > Multidisciplinary
Depositing User: Unnamed user with email admin@eprints.apopenarchive.com
Date Deposited: 06 Dec 2023 04:36
Last Modified: 06 Dec 2023 04:36
URI: http://asian.go4sending.com/id/eprint/1422

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