Neuroendocrine Mediators, Food Intake and Obesity: An Updated Narrative Review

Carella, Angelo Michele and Ciavarrella, Giuseppe and Conte, Matteo and Luca, Pasquale De and Pumpo, Michele Di and Giancola, Armando and Marinelli, Teresa and Nargiso, Martino and Ponziano, Ernestina and Benvenuto, Angelo (2022) Neuroendocrine Mediators, Food Intake and Obesity: An Updated Narrative Review. In: Current Innovations in Medicine and Medical Science Vol. 4. B P International, pp. 136-163. ISBN 978-93-5547-870-2

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This review aims to analyze the most insights about the complex and redundant molecular mechanisms which regulate food intake, focusing on the most encouraging perspectives for the treatment of Obesity. An imbalance between caloric intake and energy expenditure leads to obesity, a chronic multifactorial disease. One of the most important mechanisms governing human energy intake is the neuroendocrine system. The neuroendocrine system consists of cells that may generate and produce amines, peptides, growth factors, and biological mediators known as neurohormones that regulate a variety of biological processes through interacting with the neurological and immune systems. Some drugs, such as Sibutramine and Rimonabant, that modulate the activity of several neuroendocrine mediators (Serotonin, Noradrenaline, Endocannabinoids), have recently been shown to be effective in reducing weight excess, even though they were withdrawn due to serious side effects. Recently, promising results have been obtained in this manner with Glucagon-like Peptide-1 analogues, demonstrating significant efficacy in weight loss without side effects. More investigation into these intricate neuroendocrine circuits and their interactions with the hypothalamus in controlling food intake may lead to a more potent pharmacological therapy strategy for treating obesity and other nutritional diseases.

Item Type: Book Section
Subjects: Eprints AP open Archive > Medical Science
Depositing User: Unnamed user with email
Date Deposited: 07 Oct 2023 10:11
Last Modified: 07 Oct 2023 10:11

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